When you discuss the Patriots, you really should be discussing a Tale of Two Teams.
On the offensive side of the ball, they really have no excuses. They've had some O-line instability, but Cassel has stepped in admirably for Brady and the RBs are probably better without Maroney. They've had all the WRs available for the most part. They really have no excuse to not score points.
On the defensive side of the ball, with all the injuries, I think this team could give up 28 to B.C. High. :shrug: No indictment of the players that are there, or even the coaches (although I think the defensive coaches are underachieving). They just don't have the horses.
So, to sum, they should easily hang up 24 to 28 on Oakland, even on the road. The question is: how much will the defense give up?
A key for the Pats is special teams. With a D that sucks, they cannot afford to give up a ST touchdown, or even let the opposing offense start at midfield. They just can't.