If that is your response to this, you should reconsider the question. Let me emphasize (and slightly adjust) the important words:
So, in other words, your skillset is X (and this is shown on your resume, of course). Your particular education, skills, and experience do not just "qualify you for the job." They have prepared you specifically for this job, and to do X, which is generally important to all businesses and specifically to this particular company because of Y, which you found in your research.
But don't go overboard. You're presumably not applying to be a strategy officer. Show how you can do your job, be efficient, avoid wastefulness in terms of additional or remedial skills training, and have a history of reaching beyond your job description to take on new challenges. Have a couple of stories ready of times when you have done this or something similar at other jobs or even in school.
They want to know that you're invested enough in the interview to have researched the company more than just the website (as mentioned, LinkedIn is good, also look at Hoovers, etc., especially if you're a business/finance type guy.) They want to know that you're not going to make trouble, and you're going to focus on your work. They want to know that you're going to be engaged and trainable.
Most importantly, make sure that you tell them that while you were in school, you racked up nearly 3,000 posts on a football messageboard featuring a girly pic thread that is tens of thousands of posts long.